Lawlor, A., Cunanan, K., Cunanan, J., Paul, A., Khalili, H., Ko, D., Khan, A., Gros, R., Drysdale, T., & Bridgewater, D. (2023). Minimal kidney disease phenotype in shroom3 heterozygous null mice. Canadian Journal of Kidney Health and Disease, 10, 205435812311657. https://doi.org/10.1177/20543581231165716
Deacon, E., Li, A., Boivin, F., Dvorkin-Gheva, A., Cunanan, J., & Bridgewater, D. (2023). ß-Catenin in the kidney stroma modulates pathways and genes to regulate kidney development. Developmental Dynamics, dvdy.603. https://doi.org/10.1002/dvdy.603
Mekhael, O., Revill, S. D., Hayat, A. I., Cass, S. P., MacDonald, K., Vierhout, M., Ayoub, A., Reihani, A., Padwal, M., Imani, J., Ayaub, E., Yousof, T., Dvorkin-Gheva, A., Rullo, A., Hirota, J. A., Richards, C. D., Bridgewater, D., Stämpfli, M. R., Hambly, N., … Ask, K. (2023). Myeloid-specific deletion of activating transcription factor 6 alpha increases CD11b + macrophage subpopulations and aggravates lung fibrosis. Immunology & Cell Biology, 101(5), 412–427. https://doi.org/10.1111/imcb.12637
Burger, D., Abdelrasoul, A., Alexander, R. T., Ballermann, B., Bridgewater, D., Chan, J. S. D., Cunanan, J., Cybulsky, A. V., Gerarduzzi, C., Gunaratnam, L., Hartwig, S., Kapus, A., Kennedy, C. R. J., Lamarche, C., Myette, R. L., Nmecha, I. K., Stalker, L., Szaszi, K., Torban, E., … Takano, T. (2022). Advancing discovery research in nephrology in canada: A conference report from the 2021 molecules and mechanisms mediating kidney health and disease (M3k) scientific meeting and investigator summit. Canadian Journal of Kidney Health and Disease, 9, 205435812211448. https://doi.org/10.1177/20543581221144824
Li, A., Cunanan, J., Khalili, H., Plageman, T., Ask, K., Khan, A., Hunjan, A., Drysdale, T., & Bridgewater, D. (2022). Shroom3, a gene associated with ckd, modulates epithelial recovery after aki. Kidney360, 3(1), 51–62. https://doi.org/10.34067/KID.0003802021
Hunjan, A., Cunanan, J., Khan, A., & Bridgewater, D. (2021). Nephron progenitor cell organization and nephrogenesis is dependent on Shroom3. The FASEB Journal, 35(S1), fasebj.2021.35.S1.04445. https://doi.org/10.1096/fasebj.2021.35.S1.04445
Cunanan, J., Li, A., Khalili, H., Hunjan, A., Khan, A., Cunanan, K., Drysdale, T., & Bridgewater, D. (2021). Shroom3 regulates epithelial differentiation during tubular repair after ischemia reperfusion injury. The FASEB Journal, 35(S1), fasebj.2021.35.S1.02199. https://doi.org/10.1096/fasebj.2021.35.S1.02199
Cunanan, J., Deacon, E., Cunanan, K., Yang, Z., Ask, A., Morikawa, L., Todorova, E., & Bridgewater, D. (2020). Quercetin treatment reduces the severity of renal dysplasia in a beta-catenin dependent manner. PLOS ONE, 15(6), e0234375. https://doi.org/10.1371/journal.pone.0234375
Eliya, Yousif & Padwal, Manreet & Mishra, Anamika & Shammas, Rafaella & Anum, Khatija & Patel, Hemisha & Yousof, Tamana & Abed, Soumeya & Sehmi, Roma & Bridgewater, Darren & Labiris, Renee & Arias, Irwin & Ask, Kjetil. (2020). Development and Evaluation of Interprofessional growth assessment tool for students in Problem-Based Learning (PBL) classroom.
Platko, K., Lebeau, P. F., Gyulay, G., Lhoták, Š., MacDonald, M. E., Pacher, G., Hyun Byun, J., Boivin, F. J., Igdoura, S. A., Cutz, J.-C., Bridgewater, D., Ingram, A. J., Krepinsky, J. C., & Austin, R. C. (2020). Tdag51 (T-cell death-associated gene 51) is a key modulator of vascular calcification and osteogenic transdifferentiation of arterial smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(7), 1664–1679. https://doi.org/10.1161/ATVBAHA.119.313779
Cunanan, J., Deacon, E., Cunanan, K., Morikawa, L., Ask, A., & Bridgewater, D. (2020). Quercetin improves abnormal nephron formation in a mouse model of renal dysplasia. The FASEB Journal, 34(S1), 1–1. https://doi.org/10.1096/fasebj.2020.34.s1.02186
Deacon, E., Li, A., Boivin, F., Dvorkin-Gheva, A., Cunanan, J., & Bridgewater, D. (2020). ß-catenin in the kidney stroma modulates pathways and genes that regulate kidney development. The FASEB Journal, 34(S1), 1–1. https://doi.org/10.1096/fasebj.2020.34.s1.00313
Eliya, Yousif & Mishra, Anamika & Shammas, Rafaella & Anum, Khatija & Patel, Hemisha & Padwal, Manreet & Yousof, Tamana & Abed, Soumeya & Sehmi, Roma & Bridgewater, Darren & Labiris, Renee & Arias, Irwin & Ask, Kjetil. (2019). The McMaster Demystifying Medicine Program: a student-led platform for scientific communication and knowledge translation.
Mekhael, O., Patel, H., Imani, J., Ayaub, E., Padwal, M., Ayoub, A., Vierhout, M., El-Taweel, M., Naiel, S., Rullo, A., Hirota, J. A., Hambly, N., Bridgewater, D., Naqvi, A., Kolb, M. R. J., & Ask, K. (2019). Assessing the role of atf6? in the alternative activation of macrophages in the progression of fibrotic lung diseases. D107. MITOCHONDRIA AND ER STRESS IN HOMEOSTASIS AND REPAIR, A7232–A7232. https://doi.org/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A7232
Cunanan, J., Kitala, P., Yang, Z. T., Ask, A., & Bridgewater, D. (2019). Quercetin as a novel treatment for developmental abnormalities of the kidney. The FASEB Journal, 33(S1). https://doi.org/10.1096/fasebj.2019.33.1_supplement.326.5
Kitala, P., Cunanan, J., & Bridgewater, D. (2019). Characterization of the role of shroom3 in nephron formation. The FASEB Journal, 33(S1). https://doi.org/10.1096/fasebj.2019.33.1_supplement.208.2
Platko, K., Gyulay, G., Lebeau, P., Byun, J. H., Boivin, F., Bridgewater, D., Krepinsky, J., & Austin, R. C. (2018). Tdag51 is a key modulator of vascular calcification and osteogenic transdifferentiation of arterial smooth muscle cells. Atherosclerosis Supplements, 32, 100. https://doi.org/10.1016/j.atherosclerosissup.2018.04.304
Platko, K., Gyulay, G., Lebeau, P., Lhotá, Š., Byun, J. H., Boivin, F., Bridgewater, D., Krepinsky, J., & Austin, R. C. (2018). TDAG51 is a key modulator of vascular calcification and osteogenic transdifferentiation of arterial smooth muscle cells. The FASEB Journal, 32(S1). https://doi.org/10.1096/fasebj.2018.32.1_supplement.533.90
Padwal, M., Cheng, G., Liu, L., Boivin, F., Gangji, A. S., Brimble, K. S., Bridgewater, D., & Margetts, P. J. (2018). WNT signaling is required for peritoneal membrane angiogenesis. American Journal of Physiology-Renal Physiology, 314(6), F1036–F1045. https://doi.org/10.1152/ajprenal.00497.2017
Boivin, F. J., & Bridgewater, D. (2018). ß-Catenin in stromal progenitors controls medullary stromal development. American Journal of Physiology-Renal Physiology, 314(6), F1177–F1187. https://doi.org/10.1152/ajprenal.00282.2017
Padwal, M., Siddique, I., Wu, L., Tang, K., Boivin, F., Liu, L., Robertson, J., Bridgewater, D., West-Mays, J., Gangji, A., Brimble, K. S., & Margetts, P. J. (2016). Matrix metalloproteinase 9 is associated with peritoneal membrane solute transport and induces angiogenesis through ß-catenin signaling. Nephrology Dialysis Transplantation, gfw076. https://doi.org/10.1093/ndt/gfw076
Ayaub, E. A., Kolb, P. S., Mohammed-Ali, Z., Tat, V., Murphy, J., Bellaye, P.-S., Shimbori, C., Boivin, F. J., Lai, R., Lynn, E. G., Lhoták, Š., Bridgewater, D., Kolb, M. R., Inman, M. D., Dickhout, J. G., Austin, R. C., & Ask, K. (2016). GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis: GRP78-mediated macrophage apoptosis in pulmonary fibrosis. The Journal of Pathology, 239(4), 411–425. https://doi.org/10.1002/path.4738
Khalili, H., Sull, A., Sarin, S., Boivin, F. J., Halabi, R., Svajger, B., Li, A., Cui, V. W., Drysdale, T., & Bridgewater, D. (2016). Developmental origins for kidney disease due to shroom3 deficiency. Journal of the American Society of Nephrology, 27(10), 2965–2973. https://doi.org/10.1681/ASN.2015060621
Boivin, F. J., Sarin, S., Dabas, P., Karolak, M., Oxburgh, L., & Bridgewater, D. (2016). Stromal ß-catenin overexpression contributes to the pathogenesis of renal dysplasia: Overexpression of ß-catenin in stromal cells results in renal dysplasia. The Journal of Pathology, 239(2), 174–185. https://doi.org/10.1002/path.4713
Boivin, F. J., Sarin, S., Evans, J. C., & Bridgewater, D. (2015). The good and bad of ß-catenin in kidney development and renal dysplasia. Frontiers in Cell and Developmental Biology, 3. https://doi.org/10.3389/fcell.2015.00081
Bridgewater, D. (2015). Life as a new investigator. Canadian Journal of Kidney Health and Disease, 2, 83. https://doi.org/10.1186/s40697-015-0083-4
Boivin, F. J., Sarin, S., Lim, J., Javidan, A., Svajger, B., Khalili, H., & Bridgewater, D. (2015). Stromally expressed ß-catenin modulates wnt9b signaling in the ureteric epithelium. PLOS ONE, 10(3), e0120347. https://doi.org/10.1371/journal.pone.0120347
Bridgewater, D., Khalili, H., Sull, A., & Drysdale, T. (2015). Developmental origins for kidney disease in Shroom3 deficient mice. The FASEB Journal, 29(S1). https://doi.org/10.1096/fasebj.29.1_supplement.84.3
Sarin, S., Javidan, A., Boivin, F., Alexopoulou, I., Lukic, D., Svajger, B., Chu, S., Baradaran-Heravi, A., Boerkoel, C. F., Rosenblum, N. D., & Bridgewater, D. (2015). Insights into the renal pathogenesis in schimke immuno-osseous dysplasia: A renal histological characterization and expression analysis. Journal of Histochemistry & Cytochemistry, 63(1), 32–44. https://doi.org/10.1369/0022155414558335
Khalili, H., Drysdale, T., Sull, A., & Bridgewater, D. (2014). Shroom3 is required for nephron development (540.9). The FASEB Journal, 28(S1). https://doi.org/10.1096/fasebj.28.1_supplement.540.9
Boivin, F., & Bridgewater, D. (2014). ß-Catenin in the renal stroma regulates apoptosis via Bcl2l1 during kidney development (344.4). The FASEB Journal, 28(S1). https://doi.org/10.1096/fasebj.28.1_supplement.344.4
Sarin, S., Boivin, F., Li, A., Lim, J., Svajger, B., Rosenblum, N. D., & Bridgewater, D. (2014). ß-catenin overexpression in the metanephric mesenchyme leads to renal dysplasia genesis via cell-autonomous and non–cell-autonomous mechanisms. The American Journal of Pathology, 184(5), 1395–1410. https://doi.org/10.1016/j.ajpath.2014.01.018
Baradaran-Heravi, A., Cho, K. S., Tolhuis, B., Sanyal, M., Morozova, O., Morimoto, M., Elizondo, L. I., Bridgewater, D., Lubieniecka, J., Beirnes, K., Myung, C., Leung, D., Fam, H. K., Choi, K., Huang, Y., Dionis, K. Y., Zonana, J., Keller, K., Stenzel, P., … Boerkoel, C. F. (2012). Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. Human Molecular Genetics, 21(11), 2572–2587. https://doi.org/10.1093/hmg/dds083
Bridgewater, D., Di Giovanni, V., Cain, J. E., Cox, B., Jakobson, M., Sainio, K., & Rosenblum, N. D. (2011). ß-catenin causes renal dysplasia via upregulation of tgf?2 and dkk1. Journal of the American Society of Nephrology, 22(4), 718–731. https://doi.org/10.1681/ASN.2010050562
Ola, R., Jakobson, M., Kvist, J., Perälä, N., Kuure, S., Braunewell, K.-H., Bridgewater, D., Rosenblum, N. D., Chilov, D., Immonen, T., Sainio, K., & Sariola, H. (2011). The gdnf target vsnl1 marks the ureteric tip. Journal of the American Society of Nephrology, 22(2), 274–284. https://doi.org/10.1681/ASN.2010030316
Ola, R., Jakobson, M., Perälä, N., Kuure, S., Braunewell, K.-H., Bridgewater, D., Rosenblum, N. D., Chilov, D., Sainio, K., & Sariola, H. (2010). P110. Visinin like 1 is differentially expressed in ureteric tips upon induction or disruption of branching. Differentiation, 80, S54. https://doi.org/10.1016/j.diff.2010.09.116
Cain, J. E., Islam, E., Haxho, F., Chen, L., Bridgewater, D., Nieuwenhuis, E., Hui, C.-C., & Rosenblum, N. D. (2009). Gli3 repressor controls nephron number via regulation of wnt11 and ret in ureteric tip cells. PLoS ONE, 4(10), e7313. https://doi.org/10.1371/journal.pone.0007313
Bridgewater, D., & Rosenblum, N. D. (2009). Stimulatory and inhibitory signaling molecules that regulate renal branching morphogenesis. Pediatric Nephrology, 24(9), 1611–1619. https://doi.org/10.1007/s00467-008-1048-y
Bridgewater, D., Cox, B., Cain, J., Lau, A., Athaide, V., Gill, P. S., Kuure, S., Sainio, K., & Rosenblum, N. D. (2008). Canonical WNT/ß-catenin signaling is required for ureteric branching. Developmental Biology, 317(1), 83–94. https://doi.org/10.1016/j.ydbio.2008.02.010
Bridgewater, D. J., Dionne, J. M., Butt, M. J., Pin, C. L., & Matsell, D. G. (2008). The role of the type I insulin-like growth factor receptor (Igf-ir) in glomerular integrity. Growth Hormone & IGF Research, 18(1), 26–37. https://doi.org/10.1016/j.ghir.2007.06.003
Hartwig, S., Bridgewater, D., Di Giovanni, V., Cain, J., Mishina, Y., & Rosenblum, N. D. (2008). Bmp receptor alk3 controls collecting system development. Journal of the American Society of Nephrology, 19(1), 117–124. https://doi.org/10.1681/ASN.2007010080
Bridgewater, D. J., Ho, J., Sauro, V., & Matsell, D. G. (2005). Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway. Kidney International, 67(4), 1308–1314. https://doi.org/10.1111/j.1523-1755.2005.00208.x
Bridgewater, D. J., & Matsell, D. G. (2003). Insulin-like growth factor binding protein-2 modulates podocyte mitogenesis. Pediatric Nephrology, 18(11), 1109–1115. https://doi.org/10.1007/s00467-003-1242-x
Bridgewater, D. J. V., Mok, A., & Matsell, D. G. (2000). Expression of complement regulatory proteins in the developing human kidney. Pediatric Nephrology, 15(1–2), 36–42. https://doi.org/10.1007/s004670000390